Implementation of Intra-Operative Specimen Tomosynthesis and Impact of Re-Excision Rates for Image Guided Partial Mastectomies

Implementation of Intra-Operative Specimen Tomosynthesis and Impact of Re-Excision Rates for Image Guided Partial Mastectomies

Book A MeetingDownload Clinical Data


* Image guided localization is a valuable tool commonly utilized during partial mastectomy (PM) to ensure accurate removal of early-stage breast cancer.

* Many techniques and imaging modalities exist to confirm completeness of the initial procedure including: six (6) quadrant shaves, selective shaves, pathologic gross evaluation and margin probe use.

* Still, approximately 1 out of 5 patients require a second procedure in order to obtain a negative surgical margin.

* A promising tool, intraoperative specimen tomosynthesis allows for imaging in the OR instead of remote radiologic interpretation, overall decreasing operative time and potentially unnecessary shaves and re-excisions.


* To determine the effect of the Mozart Specimen Tomosynthesis System (Kubtec Imaging, Stratford CT) on re-excision rates for image-guided PMs.


* Re-excision rates were collected for a single surgeon over 6 years, 37 months before and 37 months after the implementation of Mozart.

* For the first 37 months, shave margins were determined by palpation and radiologist interpretation of 2D images. For the second, Mozart was used.

* Final pathology of the initial specimen, pathology of additional shave margins, and overall positive margin rate were determined for both groups.


* 561 image guided PMs were performed, 250 before use of Mozart and 311 after.

* A majority of both the pre and post Mozart groups were localized using a single wire (Table 1).

* More additional shaves were taken under the guidance of Mozart than without (Chart 1), resulting in 11.28% of the first group with positive margins compared to 5.5% of the second group, with an odds ratio of 0.458.

* The majority of positive margins contained cancer (Chart 2).


* Use of Mozart for localization versus remote radiologic interpretation for determining additional shave margins is associated with lower positive margins rates.

* Most importantly, use of Mozart was shown to discover positive margins that would have been missed based on final pathology of initial specimen alone.

* While there were significantly more shave margins taken based on selective shave margin determination, this is far fewer than the 1,866 that would be taken from full cavity shave.

* Further studies are needed to compare the two techniques.

Request your personal meeting or demo

Fill out the form and one of our exhibition managers with be in touch about scheduling your personal meeting or demo at our upcoming trade show.

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

For more news, views, & events, please visit our LinkedIn page

Click Here